Author

M. Roghanian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Organism:E. coli· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Garcia-Pino· 3 shared H. Takada· 3 shared V. Hauryliuk· 3 shared G. Akanuma· 2 shared G. C. Atkinson· 2 shared R. Murayama· 2 shared A. K. Sinha· 1 shared D. Rejman· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

A. Garcia-Pino

Mutual co-authors in cluster

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4 papers

Recent·Most cited

RelA-SpoT Homologue toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis

T. Kurata, T. Brodiazhenko, S. R. A. Oliveira, M. Roghanian, K. J. Turnbull, O. Bulvas, H. Takada, R. Pohl, A. Garcia-Pino, D. Rejman, T. Tenson, G. C. Atkinson, V. Hauryliuk

The paper investigates how four RSH toxins inhibit bacterial growth by pyrophosphorylating tRNA, disrupting protein synthesis and amino acid sensing.

bioRxiv · Apr 30, 2021Microbiology

The C-terminal RRM/ACT domain is crucial for fine-tuning the activation of 'long' RelA-SpoT Homolog enzymes by ribosomal complexes

H. Takada, M. Roghanian, V. Murina, I. Dzhygyr, R. Murayama, G. Akanuma, G. C. Atkinson, A. Garcia-Pino, V. Hauryliuk

This study shows that the RRM domain in long RSH enzymes is essential for proper ribosome-mediated activation, preventing excessive (p)ppGpp production and cytotoxicity.

bioRxiv · Jan 23, 2020Biochemistry

Ribosome association primes the stringent factor Rel for recruitment of deacylated tRNA to ribosomal A-site

H. Takada, M. Roghanian, J. Caballero-Montes, K. Van Nerom, S. Jimmy, P. Kudrin, F. Trebini, R. Murayama, G. Akanuma, A. Garcia-Pino, V. Hauryliuk

The paper reveals how RelA/SpoT Homolog factor Rel in Bacillus subtilis detects amino acid starvation by interacting with deacylated tRNA on the ribosome, triggering (p)ppGpp synthesis.

bioRxiv · Jan 17, 2020 · PreprintBiochemistry

Fatty acid starvation activates RelA by depleting lysine precursor pyruvate

A. K. Sinha, K. S. Winther, M. Roghanian, K. Gerdes

The paper shows that fatty acid starvation activates RelA in E. coli by depleting lysine and pyruvate, leading to increased antibiotic tolerance.

bioRxiv · Jul 22, 2019Microbiology