Author

G. B. Melikyan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

M. Marin· 2 shared A. Bazrafshan· 1 shared J. Carlos de la Torre· 1 shared J. H. Nunberg· 1 shared J. Steinkuhler· 1 shared J. York· 1 shared K. Salaita· 1 shared L. Zhang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiophysics

M. Marin

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Rolosense: Mechanical detection of SARS-CoV-2 using a DNA-based motor

S. Piranej, L. Zhang, A. Bazrafshan, M. Marin, G. B. Melikyan, K. Salaita

Rolosense detects SARS-CoV-2 using a DNA-based motor that stalls in the presence of viral particles, offering a rapid, low-cost, point-of-care diagnostic method.

bioRxiv · Feb 27, 2023Biophysics

Fusogenic Structural Changes in Arenavirus Glycoproteins are Associated with Viroporin Activity

Y. B. Zhang, J. York, M. A. Brindley, J. H. Nunberg, G. B. Melikyan

The paper shows that conformational changes in arenavirus glycoproteins trigger virion membrane permeabilization and acidification before fusion, suggesting a viroporin-like activity that aids viral entry.

bioRxiv · Feb 20, 2023Microbiology

Human LAMP1 accelerates Lassa virus fusion and potently promotes fusion pore dilation upon forcing viral fusion with non-endosomal membrane

Y. Zhang, J. Carlos de la Torre, G. B. Melikyan

This study investigates the role of human LAMP1 in LASV fusion, showing it accelerates pore formation but only modestly increases infection, with enhanced pore dilation when fusion is forced at the plasma membrane.

bioRxiv · Jun 1, 2022Microbiology

Interferon-Induced Transmembrane Protein 3 Blocks Fusion of Diverse Enveloped Viruses by Locally Altering Mechanical Properties of Cell Membranes

X. Guo, J. Steinkuhler, M. Marin, X. Li, W. Lu, R. Dimova, G. B. Melikyan

This study shows IFITM3 inhibits viral fusion by altering membrane curvature and stiffness, with its amphipathic helix playing a key role in these effects.

bioRxiv · Jun 25, 2020Biophysics