M. A. Brindley

Chikungunya Virus Release is Reduced by TIM-1 Receptors Through Binding of Envelope Phosphatidylserine

This study shows TIM-1 receptors reduce Chikungunya virus release by binding envelope phosphatidylserine, with virus counteracting this by decreasing TIM-1 surface levels.

Fusogenic Structural Changes in Arenavirus Glycoproteins are Associated with Viroporin Activity

The paper shows that conformational changes in arenavirus glycoproteins trigger virion membrane permeabilization and acidification before fusion, suggesting a viroporin-like activity that aids viral entry.

Phosphatidylserine within the Viral Membrane Enhances Chikungunya Virus Infectivity in a Cell-type Dependent Manner

This study shows that Chikungunya virus infectivity depends on phosphatidylserine levels in its membrane and is cell-type dependent.

Modulation of immunosuppressant drug treatment to improve SARS-CoV-2 vaccine efficacy in mice

This study shows that immunosuppressants reduce SARS-CoV-2 vaccine efficacy in mice, but temporarily stopping some drugs improves antibody responses.

Cool temperatures limit Zika virus genome replication

This study investigates how cool temperatures affect Zika virus replication in mosquito cells, finding reduced genome replication efficiency at lower temperatures.

Cell Surface Glycan Engineering Reveals that Matriglycan Alone can Recapitulate Dystroglycan Binding and Function

This study shows matriglycan can independently bind Laminin, viral proteins, and antibodies, and block viral infection, suggesting it acts as a tunable receptor.

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

Ebola virus requires phosphatidylserine scrambling activity for efficient budding and optimal infectivity

This study shows that XKR8, not TMEM16F, is essential for Ebola virus budding and infectivity by enabling phosphatidylserine (PS) externalization on the viral envelope.

Temperature drives Zika virus transmission: evidence from empirical and mathematical models

The paper estimates the thermal performance of Zika virus in Aedes aegypti and updates a temperature-dependent model to show that Zika transmission is optimized at 29°C with a thermal range of 22.7–34.7°C.

Estimating the effects of variation in viremia on mosquito susceptibility, infectiousness, and R0 of Zika in Aedes aegypti

This study examines how varying ZIKV viremia levels affect mosquito infection, infectiousness, and R0, finding increased infection and infectiousness with higher doses but no effect on dissemination or mortality.