The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture
S. Di Blasio, M. Tazzari, G. van Wigcheren, A. van Duffelen, I. Stefanini, M. Bloemendal, M. Gorris, A. Vasaturo, G. Bakdash, S. V. Hato, J. Schalkwijk, I. J. M. de Vries, E. H. van den Bogaard, C. G. Figdor
This study develops an organotypic melanoma culture to study TME effects on dendritic cell plasticity, finding tumour-driven conversion of cDC2s into CD14+ immunosuppressive DCs.
bioRxiv · Feb 27, 2019Immunology