Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
L. Weiss, J. Weiden, Y. Dölen, E. Grad, E. A. W. van Dinther, M. Schluck, L. J. Eggermont, G. van Mierlo, U. Gileadi, A. Bartolo-Ibars, R. Raave, M. A. J. Gorris, K. Verrijp, M. Valente, B. Deplancke, , R. Hammink
This paper introduces immunofilaments that expand T cells in vivo, showing efficacy against melanoma when combined with immune checkpoint blockade.
bioRxiv · Oct 14, 2022Immunology
C. M. Le Gall, A. Cammarata, L. de Haas, I. Ramos-Tomillero, J. Cuenca-Escalona, Z. Wijfjes, A. M. D. Becker, Y. Dolen, I. J. M. de Vries, C. G. Figdor, G. Florez-Grau, M. Verdoes
This study demonstrates that targeting NY-ESO-1 antigen to human cDC1s via XCL1(CC3) enhances cross-presentation and CD8+ T cell activation.
bioRxiv · Nov 30, 2021Immunology
S. Sultan, M. A. J. Gorris, E. Martynova, L. L. van der Woude, F. Buytenhuijs, S. van Wilpe, K. Verrijp, C. G. Figdor, I. J. M. de Vries, J. Textor
ImmuNet is a machine learning pipeline that identifies cell positions and phenotypes in multiplex imaging without segmentation, outperforming segmentation-based methods with error rates below 5-10%.
bioRxiv · Oct 22, 2021Immunology
C. M. Le Gall, J. M. van der Schoot, I. Ramos-Tomillero, M. Parlak Khalily, F. J. van Dalen, Z. Wijfjes, L. Smeding, D. van Dalen, A. Cammarata, K. M. Bonger, C. G. Figdor, F. A. Scheeren, M. Verdoes
This paper introduces a CRISPR-based method to engineer hybridoma cells that secrete dual-tagged Fab fragments, enabling site-specific conjugation of multiple cargos.
bioRxiv · Dec 8, 2020Biochemistry
B. Weigelin, A. T. den Boer, E. Wagena, K. Broen, H. Dolstra, R. J. de Boer, C. G. Figdor, J. Textor, P. Friedl
The paper shows that cytotoxic T cells eliminate cancer cells through multiple sublethal interactions rather than a single lethal hit, highlighting additive cytotoxicity in vivo.
bioRxiv · Apr 22, 2020Immunology
L. Querol Cano, O. Tagit, A. van Duffelen, S. Dieltjes, S. I. Buschow, T. Niki, M. Hirashima, B. Joosten, K. van den Dries, A. Cambi, C. G. Figdor, A. B. van Spriel
This study identifies intracellular Galectin-9 as essential for maintaining plasma membrane rigidity in dendritic cells, which is critical for pathogen uptake.
bioRxiv · Aug 20, 2019Cell Biology
S. Di Blasio, M. Tazzari, G. van Wigcheren, A. van Duffelen, I. Stefanini, M. Bloemendal, M. Gorris, A. Vasaturo, G. Bakdash, S. V. Hato, J. Schalkwijk, I. J. M. de Vries, E. H. van den Bogaard, C. G. Figdor
This study develops an organotypic melanoma culture to study TME effects on dendritic cell plasticity, finding tumour-driven conversion of cDC2s into CD14+ immunosuppressive DCs.
bioRxiv · Feb 27, 2019Immunology
J. M. S. van der Schoot, F. L. Fennemann, M. Valente, Y. Dolen, I. M. Hagemans, A. M. D. Becker, C. M. Le Gall, D. van Dalen, A. Cevirgel, J. A. C. van Bruggen, M. Engelfriet, M. F. Fransen, T. Caval, A. E. H. Bentlage, M. Nederend, , F. A. Scheeren
This study presents a CRISPR/HDR platform to engineer hybridoma antibodies for diverse isotypes, formats, and species, enabling functional antibody diversification.
bioRxiv · Feb 15, 2019Bioengineering
C. M. de Winde, A. L. Matthews, S. van Deventer, A. van der Schaaf, N. D. Tomlinson, E. Jansen, J. A. Eble, B. Nieswandt, H. M. McGettrick, C. G. Figdor, S. E. Acton, M. G. Tomlinson, A. B. van Spriel
This study shows that CD37 stabilizes CLEC-2 membrane expression and regulates DC migration to lymph nodes via interactions with podoplanin.
bioRxiv · Dec 22, 2017Cell Biology