Author

A. van Duffelen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

A. B. van Spriel· 2 shared C. G. Figdor· 2 shared L. Querol Cano· 2 shared A. Cambi· 1 shared A. Rodgers Furones· 1 shared A. Vasaturo· 1 shared B. Joosten· 1 shared C. G. Spruijt· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

A. B. van Spriel

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Galectin-9 interacts with Vamp-3 to regulate cytokine secretion in dendritic cells

R. Santalla Mendez, A. Rodgers Furones, R. Classens, M. Haverdil, M. Canela Capdevila, A. van Duffelen, M. ter Beest, C. G. Spruijt, M. Vermeulen, A. B. van Spriel, L. Querol Cano

This study identifies galectin-9 as essential for cytokine trafficking in dendritic cells by interacting with Vamp-3, preventing cytokine accumulation in the Golgi and promoting secretion.

bioRxiv · May 13, 2022 · PreprintCell Biology

Intracellular Galectin-9 controls dendritic cell function by maintaining plasma membrane rigidity

L. Querol Cano, O. Tagit, A. van Duffelen, S. Dieltjes, S. I. Buschow, T. Niki, M. Hirashima, B. Joosten, K. van den Dries, A. Cambi, C. G. Figdor, A. B. van Spriel

This study identifies intracellular Galectin-9 as essential for maintaining plasma membrane rigidity in dendritic cells, which is critical for pathogen uptake.

bioRxiv · Aug 20, 2019Cell Biology

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

S. Di Blasio, M. Tazzari, G. van Wigcheren, A. van Duffelen, I. Stefanini, M. Bloemendal, M. Gorris, A. Vasaturo, G. Bakdash, S. V. Hato, J. Schalkwijk, I. J. M. de Vries, E. H. van den Bogaard, C. G. Figdor

This study develops an organotypic melanoma culture to study TME effects on dendritic cell plasticity, finding tumour-driven conversion of cDC2s into CD14+ immunosuppressive DCs.

bioRxiv · Feb 27, 2019Immunology