Author

G. Bruton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

A. Coffin· 1 shared A. Patel· 1 shared A. Shillings· 1 shared A. Y. F. Li Yim· 1 shared C. E. Blunt· 1 shared C. Schofield· 1 shared C. Tallant· 1 shared D. A. Zwijnenburg· 1 shared

Activity by Year

2018-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

A. Coffin

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

M. Ghiboub, J. Koster, P. D. Craggs, A. Y. F. Li Yim, A. Shillings, S. Hutchinson, R. P. Bingham, K. Gatfield, I. L. Hageman, G. Yao, H. P. O'Keefe, A. Coffin, A. Patel, L. A. Sloan, D. J. Mitchell, , W. J. de Jonge

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

bioRxiv · Aug 10, 2020Immunology

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

P. Brennan, D. Bowkett, R. Talon, C. Tallant, C. Schofield, F. Von Delft, S. Knapp, G. Bruton

The paper identifies potential small molecule binding sites at domain-domain interfaces of epigenetic proteins using computational and experimental methods.

bioRxiv · Mar 16, 2018Biochemistry