Author

R. Talon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:protein structure prediction· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:benchmarking· 1 Organism:human· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

F. von DelftiD· 5 shared A. Douangamath· 2 shared J. Brandao-Neto· 2 shared J. T. Ng· 2 shared N. Wright· 2 shared A. G Reidenbach· 1 shared A. Wagner· 1 shared C. Schofield· 1 shared

Activity by Year

2017-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBiophysics

F. von DelftORCID

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Author profile →

5 papers

Recent·Most cited

Room-temperature crystallography reveals altered binding of small-molecule fragments to PTP1B

T. S. Mehlman, J. T. Biel, S. M. Azeem, E. R. Nelson, S. Hossain, L. E. Dunnett, N. G. Paterson, A. Douangamath, R. Talon, D. Axford, H. Orins, F. von Delft, D. A. Keedy

This study compares cryo and room-temperature crystallography of PTP1B with small-molecule fragments, showing RT reveals different binding modes and conformational changes.

bioRxiv · Nov 2, 2022Biophysics

Novel quaternary structures of the human prion protein globular domain

L. Oliveira Bortot, V. Lopes Rangel, F. A. Pavlovici, K. El Omari, A. Wagner, J. Brandao-Neto, R. Talon, F. von Delft, A. G Reidenbach, S. M Vallabh, E. Vallabh Minikel, S. Schreiber, M. Cristina Nonato

This study reports a novel dimeric and oligomeric structure of human PrPC's globular domain and explores its structural dynamics and implications for prion conversion.

bioRxiv · Nov 16, 2020Biochemistry

The Low-Cost, Semi-Automated Shifter Microscope Stage Transforms Speed and Robustness of Manual Protein Crystal Harvesting

N. Wright, F. von Delft, P. Collins, R. Talon, E. Nelson, L. Koekemoer, M. Ye, R. Nowak, J. Newman, J. T. Ng, N. Mitrovich, H. Wiggers

The Shifter microscope stage automates parts of protein crystal harvesting, increasing mounting rates and reducing manual effort while maintaining diffraction quality.

bioRxiv · Dec 20, 2019 · PreprintBiophysics

Identifying small molecule binding sites for epigenetic proteins at domain-domain interfaces

P. Brennan, D. Bowkett, R. Talon, C. Tallant, C. Schofield, F. Von Delft, S. Knapp, G. Bruton

The paper identifies potential small molecule binding sites at domain-domain interfaces of epigenetic proteins using computational and experimental methods.

bioRxiv · Mar 16, 2018Biochemistry

Gentle, fast and effective crystal soaking by acoustic dispensing

P. M. Collins, J. T. Ng, R. Talon, K. Nekrosiute, T. Krojer, A. Douangamath, J. Brandao-Neto, N. Wright, N. M. Pearce, F. von Delft

The paper describes a high-throughput method for crystal soaking using acoustic droplet ejection, showing it is gentle, fast, and effective for generating protein-ligand complexes.

Acta Crystallographica Section D Structural Biology · Mar 6, 2017Peer-reviewedBiophysics