Author

S. Hutchinson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Coffin· 1 shared A. Patel· 1 shared A. Shillings· 1 shared A. Y. F. Li Yim· 1 shared B. T. Chait· 1 shared C. E. Blunt· 1 shared C. F. Collett· 1 shared C. Kitson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperImmunology

A. Coffin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Mex67 paralogs mediate division of labor in trypanosome RNA processing and export.

S. O. Obado, M. Stein, E. Hegedusova, W. Zhang, S. Hutchinson, L. Glover, Z. Paris, B. T. Chait, M. C. Field, M. P. Rout

This study identifies distinct roles for three Mex67 paralogs in trypanosome RNA processing and export, showing non-redundant functions in mRNA export and ribosome biogenesis.

bioRxiv · Jun 27, 2022 · PreprintCell Biology

Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140

M. Ghiboub, J. Koster, P. D. Craggs, A. Y. F. Li Yim, A. Shillings, S. Hutchinson, R. P. Bingham, K. Gatfield, I. L. Hageman, G. Yao, H. P. O'Keefe, A. Coffin, A. Patel, L. A. Sloan, D. J. Mitchell, , W. J. de Jonge

This study identifies SP140 as a druggable epigenetic reader and therapeutic target for Crohn's disease by showing that its inhibition reduces inflammatory macrophage activation and cytokine expression.

bioRxiv · Aug 10, 2020Immunology

Chemogenomic profiling of anti-leishmanial efficacy and resistance in the related kinetoplastid parasite Trypanosoma brucei

C. F. Collett, C. Kitson, N. Baker, H. B. Steele-Stallard, M.-V. Santrot, S. Hutchinson, D. Horn, S. Alsford

This study uses a genome-scale RNAi screen in Trypanosoma brucei to identify drug efficacy determinants for anti-leishmanial drugs, revealing novel targets and resistance mechanisms.

bioRxiv · Apr 13, 2019Microbiology