In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3
G. Callejo, L. A. Pattison, J. C. Greenhalgh, S. Chakrabarti, E. Andreopoulou, J. R. Hockley, E. Smith, T. Rahman
The paper identifies guanabenz and sephin1 as new allosteric modulators of ASIC3 through in silico screening of FDA-approved drugs and electrophysiological validation.
bioRxiv · Dec 18, 2019Pharmacology & Toxicology