Sensitisation of colonic nociceptors by IL-13 is dependent on JAK and p38 MAPK activity
K. H. Barker, J. P. Higham, L. A. Pattison, I. P. Chessell, F. Welsh, E. S. J. Smith, D. C. Bulmer
This study shows IL-13 sensitizes colonic nociceptors via JAK and p38 MAPK signaling, offering therapeutic targets for visceral pain in gastrointestinal diseases.
bioRxiv · Oct 26, 2022 · PreprintPhysiology