Author

J. R. Hockley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Physiology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:electrophysiology· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

E. S. J. Smith· 3 shared D. C. Bulmer· 2 shared L. W. Paine· 2 shared T. Rahman· 2 shared A. J. Brown· 1 shared A. Loth· 1 shared D. M. Gomes· 1 shared D. Sagnat· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPharmacology & Toxicology

E. S. J. Smith

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

M. Y. Meng, L. W. Paine, D. Sagnat, I. Bello, S. Oldroyd, F. Javid, M. T. Harper, J. R. Hockley, E. S. J. Smith, R. M. Owens, L. Alric, E. Buscail, F. Welsh, N. Vergnolle, D. C. Bulmer

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

bioRxiv · Apr 12, 2024Pharmacology & Toxicology

GPR35 inhibits TRPA1-mediated colonic afferent hypersensitivity through suppression of Substance P release

R. A. Gupta, J. P. Higham, P. Urriola-Munoz, K. H. Barker, L. W. Paine, J. Ghooraroo, J. R. Hockley, T. Rahman, E. S. J. Smith, A. J. Brown, R. Suzuki, D. C. Bulmer

This paper identifies GPR35 as a target for non-opioid analgesics by showing it inhibits TRPA1-mediated colonic hypersensitivity through suppression of Substance P release.

bioRxiv · Sep 12, 2023 · PreprintPhysiology

Gut Reaction: The Impact of a Film on Public Understanding of Gastrointestinal Conditions

D. M. Gomes, A. Loth, J. R. Hockley, E. S. J. Smith

This paper evaluates a short film's impact on public understanding and stigma around chronic gastrointestinal conditions through surveys and interviews.

bioRxiv · Sep 5, 2021Scientific Communication & Education

In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3

G. Callejo, L. A. Pattison, J. C. Greenhalgh, S. Chakrabarti, E. Andreopoulou, J. R. Hockley, E. Smith, T. Rahman

The paper identifies guanabenz and sephin1 as new allosteric modulators of ASIC3 through in silico screening of FDA-approved drugs and electrophysiological validation.

bioRxiv · Dec 18, 2019Pharmacology & Toxicology