Oxidation-sensitive cysteines drive IL-38 amyloid formation
A. Diaz-Barreiro, G. Cereghetti, J. Tonacini, D. Talabot-Ayer, S. Kieffer-Jaquinod, A. Huard, C. Swale, Y. Coute, M. Peter, A. Frances-Monerris, G. Palmer
This study identifies oxidation-sensitive cysteines in IL-38 that drive amyloid formation under oxidative stress, suggesting a new biological role for IL-38 in epithelial barriers.
bioRxiv · Mar 26, 2023Cell Biology