Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models
S. Kicka, N. Hanna, G. Chiriano, C. Harrison, H. Ouertatani Sakouhi, V. Trofimov, A. Kranjc, H. Hilbi, P. Cosson, L. Scapozza, T. Soldati
This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.
bioRxiv · Dec 17, 2018Microbiology