Author

H. Hilbi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:clustering· 1

Frequent Co-Authors

C. Barisch· 3 shared T. Soldati· 3 shared A. Anand· 2 shared D. Becher· 2 shared D. Hüsler· 2 shared F. Letourneur· 2 shared N. Hanna· 2 shared S. Maass· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

C. Barisch

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

The Legionella autoinducer LAI-1 is delivered by outer membrane vesicles to promote inter-bacterial and inter-kingdom signaling

M. Fan, P. Kiefer, P. Charki, C. Hedberg, J. Seibel, J. Vorholt, H. Hilbi

This paper identifies LAI-1 as a signaling molecule secreted by Legionella pneumophila via outer membrane vesicles, promoting inter-bacterial and inter-kingdom communication.

bioRxiv · Aug 22, 2023 · PreprintMicrobiology

ER-dependent membrane repair of mycobacteria-induced vacuole damage

A. Anand, A.-C. Mazur, P. Rosell-Arevalo, R. Franzkoch, L. Breitsprecher, S. A. Listian, S. V. Hüttel, D. Müller, D. G. Schäfer, S. Vormittag, H. Hilbi, M. Maniak, M. Gutierrez, C. Barisch

This study identifies OSBP8 as an ER-dependent lipid transfer protein involved in membrane repair of mycobacteria-induced vacuole damage, which is critical for host defense against M. tuberculosis.

bioRxiv · Apr 17, 2023Cell Biology

The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

D. Hüsler, P. Stauffer, B. Keller, D. Böck, T. Steiner, A. Ostrzinski, B. Striednig, L. Swart, F. Letourneur, S. Maass, D. Becher, W. Eisenreich, M. Pilhofer, H. Hilbi

This paper shows that Sey1 facilitates lipid droplet and FadL-dependent fatty acid metabolism in Legionella pneumophila by promoting interactions between the Legionella-containing vacuole and lipid droplets.

bioRxiv · Dec 5, 2022Microbiology

The Legionella-driven PtdIns(4)P gradient at LCV-ER membrane contact sites promotes Vap-, OSBP- and Sac1-dependent pathogen vacuole remodeling

S. Vormittag, D. Hüsler, I. Haneburger, T. Kroniger, A. Anand, M. Prantl, C. Barisch, S. Maass, D. Becher, F. Letourneur, H. Hilbi

bioRxiv · Jun 17, 2022Microbiology

The Legionella Lqs-LvbR regulatory network controls temperature-dependent growth onset and bacterial cell density

R. Hochstrasser, H. Hilbi

This study shows the Lqs-LvbR network regulates temperature-dependent growth and cell density in Legionella pneumophila, with LvbR playing a key role at higher temperatures.

bioRxiv · Oct 12, 2021Microbiology

Systematic exploration of Escherichia coli phage-host interactions with the BASEL phage collection

E. Maffei, A. Shaidullina, M. Burkolter, V. Druelle, L. Willi, F. Estermann, S. Michaelis, H. Hilbi, D. S. Thaler, A. Harms

The paper systematically explores Escherichia coli phage-host interactions using a new phage collection, revealing patterns in phage phenotypes and immunity system potency.

bioRxiv · Mar 8, 2021Microbiology

Zinc intoxication of Mycobacterium marinum during Dictyostelium discoideum infection is counteracted by induction of the pathogen Zn2+ exporter CtpC

L. H. Lefrancois, V. Kalinina, E. Cardenal-Munoz, N. Hanna, H. Koliwer-Brandl, J. Appiah, F. Leuba, H. Hilbi, T. Soldati, C. Barisch

This study shows that M. marinum infection induces Zn2+ accumulation in D. discoideum phagosomes, which is counteracted by bacterial upregulation of the Zn2+ exporter CtpC.

bioRxiv · Mar 15, 2019Cell Biology

Identification of novel anti-bacterial compounds from a chemically highly diverse pathways-based library using phenotypic screens in amoebae host models

S. Kicka, N. Hanna, G. Chiriano, C. Harrison, H. Ouertatani Sakouhi, V. Trofimov, A. Kranjc, H. Hilbi, P. Cosson, L. Scapozza, T. Soldati

This study screens a diverse chemical library in amoeba models to identify anti-bacterial compounds effective against M. marinum and L. pneumophila, finding 64 active compounds with varying efficacy.

bioRxiv · Dec 17, 2018Microbiology

PIKfyve/Fab1 is required for efficient V-ATPase and hydrolase delivery to phagosomes, phagosomal killing, and restriction of Legionella infection

C. M. Buckley, V. L. Heath, A. Gueho, C. Bosmani, P. Knobloch, P. Sikakana, N. Personnic, S. K. Dove, R. H. Michell, R. Meier, H. Hilbi, T. Soldati, R. H. Insall, J. King

This paper shows that PIKfyve is essential for delivering V-ATPase and proteases to phagosomes, enabling acidification and killing of bacteria, and protecting against Legionella infection.

bioRxiv · Jul 17, 2018Cell Biology