Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor
M. H. Chasse, B. K. Johnson, E. A. Boguslawski, K. M. Sorensen, L. Heo, Z. B. Madaj, I. Beddows, G. E. Foxa, S. M. Kitchen-Goosen, B. O. Williams, T. J. Triche, P. J. Grohar
This paper shows that targeting the SWI/SNF complex with mithramycin and its analogue EC8042 induces epigenetic reprogramming and durable tumor regression in rhabdoid tumors.
bioRxiv · Dec 3, 2019 · PreprintCancer Biology