Author

T. J. Triche

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 5 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:clustering· 2 Assay:DNA methylation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

B. K. Johnson· 2 shared G. Ramsingh· 2 shared Y. Liu· 2 shared Z. B. Madaj· 2 shared A. Bergsma· 1 shared A. Chatterjee· 1 shared A. Drougard· 1 shared A. L. Patterson· 1 shared

Activity by Year

2017-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

B. K. Johnson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Developmental priming of cancer susceptibility

I. Panzeri, L. Fagnocchi, S. Apostle, M. Tompkins, E. Wolfrum, Z. Madaj, G. Hostetter, Y. Liu, K. Schaefer, C.-H. Yang, A. Bergsma, A. Drougard, E. Dror, PERMUTE, D. Chandler, , J. A. Pospisilik

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Nature Cancer · Jan 24, 2025Peer-reviewedCancer Biology

Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth

E. Vasileva, M. Warren, T. J. Triche, J. F. Amatruda

This study develops a zebrafish model of Ewing sarcoma and identifies heparan sulfate proteoglycan metabolism as a driver of tumor growth, showing that targeting this pathway reduces tumorigenicity.

bioRxiv · May 25, 2021Cancer Biology

Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor

M. H. Chasse, B. K. Johnson, E. A. Boguslawski, K. M. Sorensen, L. Heo, Z. B. Madaj, I. Beddows, G. E. Foxa, S. M. Kitchen-Goosen, B. O. Williams, T. J. Triche, P. J. Grohar

This paper shows that targeting the SWI/SNF complex with mithramycin and its analogue EC8042 induces epigenetic reprogramming and durable tumor regression in rhabdoid tumors.

bioRxiv · Dec 3, 2019 · PreprintCancer Biology

Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids.

J. W. George, H. Fan, B. K. Johnson, A. Chatterjee, A. L. Patterson, J. Koeman, M. Adams, Z. B. Madaj, D. W. Chesla, E. E. Marsh, T. J. Triche, H. Shen, J. M. Teixeira

This study integrates epigenome, exome, and transcriptome data to identify molecular subtypes and homeotic transformation in uterine fibroids.

bioRxiv · Oct 29, 2018Physiology

Comprehensive characterization of pediatric AML reveals diverse fusion oncoproteins and age-specific mutational interactions

H. Bolouri, J. E. Farrar, T. J. Triche, R. E. Ries, E. L. Lim, T. A. Alonzo, Y. Ma, R. Moore, A. Mungall, M. A. Marra, J. Zhang, X. Ma, Y. Liu, Y. Liu, J. M. Guidry Auvil, , S. Meshinchi

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.

bioRxiv · Oct 10, 2017Cancer Biology

Suppression of Transposable Elements in Leukemic Stem Cells

A. R. Colombo, A. Zubair, D. Thiagarajan, S. Nuzhdin, T. J. Triche, G. Ramsingh

This study investigates TE suppression in AML and MDS, finding that LSCs and high-risk MDS cases show reduced TE expression, suggesting TE suppression as a mechanism for immune escape.

bioRxiv · Jul 28, 2017Cancer Biology