B. K. Johnson

A Novel Humanized Immune Stroma PDX Cancer Model for Therapeutic Studies

This paper develops a humanized immune stroma PDX model to better reflect therapeutic resistance and patient response to immunotherapies.

Carbon dioxide regulates Mycobacterium tuberculosis PhoPR signaling and virulence

This study shows that CO2 regulates Mtb PhoPR signaling and virulence, with CanB playing a key role in virulence and CO2-dependent gene induction.

Games of risk and reward in carnivore communities

The paper examines how dominant cougars influence subordinate carnivores through both provisioning and predation, revealing complex risk-reward interactions in a carnivore community.

Evaluating and integrating spatial capture-recapture models with data of variable individual identifiability

The paper evaluates spatial capture-recapture models using different data types to estimate wildlife population densities and finds hybrid models with multiple data sources provide the most precise estimates.

Direct therapeutic targeting of SWI/SNF induces epigenetic reprogramming and durable tumor regression in rhabdoid tumor

This paper shows that targeting the SWI/SNF complex with mithramycin and its analogue EC8042 induces epigenetic reprogramming and durable tumor regression in rhabdoid tumors.

Elizabethkingia anophelis response to iron stress: physiologic, genomic, and transcriptomic analyses

This study examines how E. anophelis responds to iron stress through transcriptomic analysis, revealing gene expression changes and physiological adaptations in different iron conditions.

Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids.

This study integrates epigenome, exome, and transcriptome data to identify molecular subtypes and homeotic transformation in uterine fibroids.

Acidic pH-dependent depletion of Mycobacterium tuberculosis thiol pools potentiates antibiotics and oxidizing agents

This study identifies AC2P36 as a compound that depletes Mtb thiol pools at acidic pH, enhancing sensitivity to antibiotics and oxidizing agents.