Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease
E. A. MacDonald, G. Frey, M. Namchuk, S. C. Harrison, S. M. Hinshaw, I. W. Windsor
This study presents crystal structures of SARS-CoV-2 Mpro bound to viral substrate peptides, revealing how peptide sequences influence catalytic efficiency and providing insights for antiviral drug design.
bioRxiv · Apr 20, 2021Biochemistry