S. C. Harrison

A communication hub for phosphoregulation of kinetochore-microtubule attachment

The paper identifies a communication hub involving Mps1 and Aurora B kinases that regulates kinetochore-microtubule attachment through interactions with Ndc80c and Dam1c.

The rotavirus VP5*/VP8* conformational transition permeabilizes membranes to Ca2+

This study confirms that the rotavirus VP5*/VP8* conformational transition enables membrane permeabilization to Ca2+ through C-terminal segment insertion.

Structures of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface

The paper uses AlphaFold 2 to predict and validate the structure of the Ndc80 complex and its interactions with the Dam1 complex, revealing how phosphorylation regulates kinetochore-microtubule attachments.

Infant antibody repertoires during the first two years of influenza vaccination

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

Recall of B cell memory depends on relative locations of prime and boost

The study shows that memory B cells form recall germinal centers more effectively when boosts are given at the same site as the initial immunization, leading to higher mutation levels and avidity in BCRs.

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

This study presents crystal structures of SARS-CoV-2 Mpro bound to viral substrate peptides, revealing how peptide sequences influence catalytic efficiency and providing insights for antiviral drug design.

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

The structural basis for Ulp2 recruitment to the kinetochore

This study identifies a mechanism for regulated kinetochore sumoylation by showing that Ulp2 recruitment to Ctf3/CENP-I controls sumoylation levels and chromosome segregation.

Structural Basis of Stu2 Recruitment to Yeast Kinetochores

This study identifies the structural basis of Stu2 recruitment to yeast kinetochores by showing its interaction with the Ndc80 complex, which is essential for tension-dependent stabilization of kinetochore-microtubule attachments.

The structural basis for kinetochore stabilization by Cnn1/CENP-T

This study presents a high-resolution structure of the Ctf3 complex bound to Cnn1-Wip1, revealing their role in kinetochore stabilization and feedback regulation across yeast and vertebrates.

Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate

This study presents cryo-EM structures of the E. coli ClpXP protease complex, revealing how ClpX interacts with ClpP and substrates, and proposes models for its ATP-dependent proteolytic mechanism.

How small-molecule inhibitors of dengue-virus infection interfere with viral membrane fusion

The paper studies how small-molecule inhibitors block dengue virus membrane fusion by targeting the envelope protein's conformational change, showing that ~15 bound molecules per particle prevent fusion.