Author

E. A. MacDonald

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

S. C. Harrison· 2 shared A. A. M. Elbassioni· 1 shared A. Bradley· 1 shared A. G. Schmidt· 1 shared A. Gautam· 1 shared A. Griffths· 1 shared A. Zuiani· 1 shared B. Chen· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

S. C. Harrison

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Inhibiting Runx1 protects heart function after myocardial infarction

T. P. Martin, E. A. MacDonald, A. Bradley, H. Watson, P. Saxena, E. A. Rog-Zielinska, S. Fisher, A. A. M. Elbassioni, O. Almuzaini, C. Booth, M. Campbell, P. Herzyk, K. Blyth, C. Nixon, L. Zentilin, , C. M. Loughrey

This study shows that inhibiting RUNX1 improves heart function after myocardial infarction by preserving contractility and mitochondrial function.

bioRxiv · Feb 17, 2022 · PreprintPathology

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

E. A. MacDonald, G. Frey, M. Namchuk, S. C. Harrison, S. M. Hinshaw, I. W. Windsor

This study presents crystal structures of SARS-CoV-2 Mpro bound to viral substrate peptides, revealing how peptide sequences influence catalytic efficiency and providing insights for antiviral drug design.

bioRxiv · Apr 20, 2021Biochemistry

Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike

P. Tong, A. Gautam, I. Windsor, M. Travers, Y. Chen, N. Garcia, N. Whiteman, L. McKay, F. J. N. Lelis, S. Habibi, Y. Cai, L. J. Rennick, W. P. Duprex, K. McCarthy, C. L. Lavine, , D. R. Wesemann

The paper maps memory B cell receptors against SARS-CoV-2 spike variants, identifying 7 mAb competition groups and their epitopic regions, and shows their cross-reactivity and neutralization properties.

bioRxiv · Mar 10, 2021Immunology