Author

I. W. Windsor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 2 Assay:proteomics· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. G. Schmidt· 2 shared A. Watanabe· 2 shared M. Kuraoka· 2 shared S. C. Harrison· 2 shared A. B. Balazs· 1 shared A. Dermenci· 1 shared A. Flick· 1 shared A. R. Roffler· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. G. Schmidt

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Structural basis for CCR6 modulation by allosteric antagonists

D. J. Wasilko, B. S. Gerstenberger, K. A. Farley, W. Li, J. Alley, M. E. Schnute, R. J. Unwalla, J. Victorino, K. K. Crouse, R. Ding, P. V. Sahasrabudhe, F. Vincent, R. K. Frisbie, A. Dermenci, A. Flick, , H. Wu

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

bioRxiv · Apr 5, 2024Biochemistry

An epitope-enriched immunogen increases site targeting in germinal centers

T. M. Caradonna, I. W. Windsor, A. R. Roffler, S. Song, A. Watanabe, G. Kelsoe, M. Kuraoka, A. G. Schmidt

This study shows that an epitope-enriched immunogen preferentially expands RBS-directed antibody responses compared to non-enriched immunogens.

bioRxiv · Dec 1, 2022 · PreprintImmunology

Infant antibody repertoires during the first two years of influenza vaccination

M. Kuraoka, N. C. Curtis, A. Watanabe, H. Tanno, S. Shin, K. Ye, E. Macdonald, O. Lavidor, S. Kong, T. Von Holle, I. W. Windsor, G. C. Ippolito, G. Georgiou, E. B. Walter, G. H. Kelsoe, , J. Lee

This paper studies how influenza vaccination in infants shapes their antibody responses, finding that vaccination can lead to immune imprinting similar to infection, with shifts in B-cell specificity and adult-like antibody repertoires after the second year.

bioRxiv · Sep 13, 2022Immunology

Recognition of Divergent Viral Substrates by the SARS-CoV-2 Main Protease

E. A. MacDonald, G. Frey, M. Namchuk, S. C. Harrison, S. M. Hinshaw, I. W. Windsor

This study presents crystal structures of SARS-CoV-2 Mpro bound to viral substrate peptides, revealing how peptide sequences influence catalytic efficiency and providing insights for antiviral drug design.

bioRxiv · Apr 20, 2021Biochemistry

Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif

B. M. Hauser, M. Sangesland, K. J. St. Denis, I. W. Windsor, J. Feldman, E. C. Lam, T. Kannegieter, A. B. Balazs, D. Lingwood, A. G. Schmidt

This study designs immunogens that focus immune responses to the SARS-CoV-2 receptor binding motif, enhancing neutralizing antibody breadth against related sarbecoviruses.

bioRxiv · Mar 15, 2021 · PreprintImmunology