Author

G. Gambardella

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. Viscido· 2 shared S. Pellecchia· 2 shared A. La Regina· 1 shared A. Skinner· 1 shared D. Achkova· 1 shared D. di Bernardo· 1 shared E. Pedone· 1 shared F. D. Ciccarelli· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

G. Viscido

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Predicting drug response from single-cell expression profiles of tumours

S. Pellecchia, G. Viscido, G. Gambardella, G. Gambardella

This paper introduces DREEP, a method to predict single-cell drug sensitivity from transcriptomic data, validated using cancer cell lines and applied to breast cancer cells to identify targeted drugs.

bioRxiv · Jun 1, 2023Cancer Biology

Single cell lineage tracing reveals subclonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer.

S. Pellecchia, M. Franchini, G. Viscido, R. Arnese, G. Gambardella

The paper uses single-cell lineage tracing and deep learning to study anti-EGFR therapy resistance in TNBC, identifying IGFBP2 as a driver of resistance and predicting afatinib sensitivity.

bioRxiv · Apr 4, 2023Cancer Biology

β-catenin perturbations control differentiation programs in mouse embryonic stem cells

E. Pedone, M. Failli, G. Gambardella, R. De Cegli, A. La Regina, D. di Bernardo, L. Marucci

This study shows that moderate β-catenin levels in β-catenin null mouse ESCs promote specific differentiation programs towards mesoderm or endoderm depending on induction timing.

bioRxiv · May 15, 2020Cell Biology

O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancer

V. Tajadura-Ortega, G. Gambardella, A. Skinner, K. Ter-Borch Gram Schjoldager, R. Beatson, R. Graham, D. Achkova, J. Taylor-Papadimitriou, F. D. Ciccarelli, J. Burchell

The paper shows that O-linked glycosylation differences in breast cancer cells lead to distinct gene expression signatures via differential EGFR nuclear translocation.

bioRxiv · Jul 25, 2019Cancer Biology