R. Graham

Efficacy of Host Cell Serine Protease Inhibitor MM3122 against SARS-CoV-2 for Treatment and Prevention of COVID-19

This paper demonstrates that MM3122, a host cell serine protease inhibitor, effectively inhibits SARS-CoV-2 replication and reduces disease severity in mice, both prophylactically and therapeutically.

Predicting vertical and shear ground reaction forces during walking and jogging using wearable plantar pressure insoles

This study uses LSTM neural networks to predict vertical and shear ground reaction forces from plantar pressure insole data during walking and jogging, showing higher accuracy for walking than jogging.

Validity and sensitivity of an inertial measurement unit-driven biomechanical model of motor variability for gait

This study evaluates the validity and sensitivity of an IMU-driven biomechanical model for assessing gait motor variability in healthy adults.

Cancer-associated hypersialylated MUC1 drives the differentiation of monocytes into macrophages with a pathogenic phenotype

This study identifies MUC1-ST as a driver of monocyte differentiation into pathogenic macrophages in the tumor microenvironment, associated with poor breast cancer prognosis.

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

This study demonstrates that the antiviral NHC/EIDD-2801 inhibits SARS-CoV-2 and multiple coronaviruses, showing therapeutic efficacy and oral bioavailability in mice.

Trypsin treatment unlocks barrier for zoonotic coronaviruses infection

This study shows that proteolytic cleavage, not receptor binding, is the main barrier for two MERS-like bat coronaviruses to infect human cells, and that trypsin treatment can overcome this barrier.

O-linked mucin-type glycosylation regulates the transcriptional programme downstream of EGFR in breast cancer

The paper shows that O-linked glycosylation differences in breast cancer cells lead to distinct gene expression signatures via differential EGFR nuclear translocation.

Combination attenuation offers strategy for live-attenuated coronavirus vaccines

This study shows combining NSP16 mutation with other attenuating mutations creates a safe and effective live-attenuated coronavirus vaccine that works in aged mice and against heterologous challenges.