Single cell lineage tracing reveals subclonal dynamics of anti-EGFR therapy resistance in triple negative breast cancer.
S. Pellecchia, M. Franchini, G. Viscido, R. Arnese, G. Gambardella
The paper uses single-cell lineage tracing and deep learning to study anti-EGFR therapy resistance in TNBC, identifying IGFBP2 as a driver of resistance and predicting afatinib sensitivity.
bioRxiv · Apr 4, 2023Cancer Biology