mRNA vaccines and hybrid immunity use different B cell germlines to neutralize Omicron BA.4 and BA.5
E. Andreano, I. Paciello, G. Pierleoni, G. Maccari, G. Antonelli, V. Abbiento, P. Pileri, L. Benincasa, G. Giglioli, G. Piccini, C. De Santi, C. Sala, D. Medini, E. Montomoli, P. Maes, R. Rappuoli
The paper compares neutralizing antibodies against Omicron BA.4 and BA.5 from mRNA-vaccinated individuals and those with hybrid immunity, finding differences in epitope targeting and B cell germlines used.
bioRxiv · Aug 4, 2022 · PreprintImmunology