Author

G. Maccari

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Organism:bacteria (other)· 1 Research Focus:cell-cell communication· 1 Research Focus:clustering· 1

Frequent Co-Authors

I. Paciello· 5 shared R. Rappuoli· 5 shared E. Andreano· 4 shared C. De Santi· 3 shared C. Sala· 3 shared D. Medini· 3 shared E. Pantano· 3 shared G. Antonelli· 3 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

I. Paciello

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

B cell maturation restored ancestral germlines to control Omicron BA.2.86

I. Paciello, G. Pierleoni, E. Pantano, G. Antonelli, P. Pileri, G. Maccari, D. Cardamone, G. Realini, F. Perrone, M. M. Neto, S. Pozzessere, M. Fabbiani, F. Panza, I. Rancan, M. Tumbarello, , E. Andreano

The paper analyzes neutralizing antibodies from vaccinated and hybrid immune individuals to show that restored B cell germlines enhance neutralization against SARS-CoV-2 variants like BA.2.86.

bioRxiv · Mar 3, 2024 · PreprintImmunology

Anti-capsule human monoclonal antibodies protect against hypervirulent and pandrug-resistant Klebsiella pneumoniae

E. Roscioli, V. Zucconi Galli Fonseca, S. S. Bosch, I. Paciello, G. Maccari, G. Batani, S. Stazzoni, G. Cardinali, G. Tiseo, C. Giordano, Y. Shen, L. Capoccia, M. Ridelfi, M. Troisi, N. Manganaro, , R. Rappuoli

This study isolates human monoclonal antibodies against hypervirulent, pandrug-resistant Klebsiella pneumoniae and identifies capsule-specific antibodies as protective against bloodstream infection.

bioRxiv · Feb 14, 2024 · PreprintMicrobiology

High-resolution map of the Fc-functions mediated by COVID-19 neutralizing antibodies

I. Paciello, G. Maccari, E. Pantano, E. Andreano, R. Rappuoli

This study maps Fc-functions of 482 SARS-CoV-2 neutralizing antibodies, showing that potent neutralizers may have weak Fc-functions and that Fc-functions are influenced by epitope targeting and B cell germlines.

bioRxiv · Jul 10, 2023Immunology

mRNA vaccines and hybrid immunity use different B cell germlines to neutralize Omicron BA.4 and BA.5

E. Andreano, I. Paciello, G. Pierleoni, G. Maccari, G. Antonelli, V. Abbiento, P. Pileri, L. Benincasa, G. Giglioli, G. Piccini, C. De Santi, C. Sala, D. Medini, E. Montomoli, P. Maes, R. Rappuoli

The paper compares neutralizing antibodies against Omicron BA.4 and BA.5 from mRNA-vaccinated individuals and those with hybrid immunity, finding differences in epitope targeting and B cell germlines used.

bioRxiv · Aug 4, 2022 · PreprintImmunology

COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody response

E. Andreano, I. Paciello, G. Pierleoni, G. Piccini, V. Abbiento, G. Antonelli, P. Pileri, N. Manganaro, E. Pantano, G. Maccari, S. Marchese, L. Donnici, L. Benincasa, G. Giglioli, M. Leonardi, , R. Rappuoli

This study examines how a third mRNA vaccine dose enhances neutralizing antibody responses against SARS-CoV-2 variants by expanding specific B cell germlines and altering the antibody repertoire.

bioRxiv · May 9, 2022 · PreprintImmunology