L. Donnici

Nirmatrelvir treatment blunts the development of antiviral adaptive immune responses in SARS-CoV-2 infected mice

This study shows that nirmatrelvir treatment in SARS-CoV-2 infected mice reduces antibody and T cell responses, leading to weaker memory cell recruitment upon secondary challenge.

Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody

The paper evaluates the potency of mAb J08 against SARS-CoV-2 variants using cell-based assays and cryo-EM, showing its resistance to escape mutations and broad binding capability.

COVID-19 mRNA third dose induces a unique hybrid immunity-like antibody response

This study examines how a third mRNA vaccine dose enhances neutralizing antibody responses against SARS-CoV-2 variants by expanding specific B cell germlines and altering the antibody repertoire.

Controlled administration of aerosolized SARS-CoV-2 to K18-hACE2 transgenic mice uncouples respiratory infection and anosmia from fatal neuroinvasion

This study develops an aerosolized SARS-CoV-2 infection model in K18-hACE2 mice that replicates respiratory symptoms without fatal neuroinvasion, offering a more accurate representation of human COVID-19 pathogenesis.

COVID-eVax, an electroporated plasmid DNA vaccine candidate encoding the SARS-CoV-2 Receptor Binding Domain, elicits protective immune responses in animal models of COVID-19

This paper evaluates a DNA vaccine candidate, COVID-eVax, which induces strong neutralizing antibodies and T cell responses against SARS-CoV-2 in animal models, showing protective effects against viral challenge.