Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function
P. A. Renauer, J. J. Park, M. Bai, A. Acosta, W.-H. Lee, G. H. Lin, Y. Zhang, X. Dai, G. Wang, Y. Errami, T. Wu, P. Clark, L. Ye, Q. Yang, S. Chen
The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.
bioRxiv · Mar 14, 2023 · PreprintCancer Biology