Author

P. A. Renauer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:drug response / drug discovery· 5 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3

Frequent Co-Authors

S. Chen· 8 shared L. Peng· 5 shared Q. Lin· 5 shared Z. Fang· 5 shared J. J. Park· 4 shared K. Suzuki· 4 shared L. Yang· 4 shared M. Bai· 4 shared

Activity by Year

2022-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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8 shared papersImmunology

S. Chen

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Perturbomics of tumor-infiltrating NK cells

L. Peng, P. A. Renauer, L. Ye, L. Yang, J. J. Park, R. D. Chow, Y. Zhang, Q. Lin, M. Bai, A. Sanchez, Y. Zhang, S. Z. Lam, S. Chen

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

bioRxiv · Mar 14, 2023 · PreprintImmunology

CTLA-4 tail fusion enhances CAR-T anti-tumor immunity

X. Zhou, H. Cao, S.-Y. Fang, R. D. Chow, K. Tang, M. Majety, M. Bai, M. B. Dong, P. A. Renauer, X. Shang, K. Suzuki, A. Levchenko, S. Chen

This study enhances CAR-T cell efficacy by fusing CTLA-4 cytoplasmic tails to CARs, improving anti-tumor responses in a leukemia model.

bioRxiv · Mar 14, 2023 · PreprintImmunology

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

P. A. Renauer, J. J. Park, M. Bai, A. Acosta, W.-H. Lee, G. H. Lin, Y. Zhang, X. Dai, G. Wang, Y. Errami, T. Wu, P. Clark, L. Ye, Q. Yang, S. Chen

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

bioRxiv · Mar 14, 2023 · PreprintCancer Biology

Polyvalent mRNA vaccination elicited potent immune response to monkeypox surface antigens

Z. Fang, P. A. Renauer, K. Suzuki, S. Chen

This study develops a polyvalent mRNA vaccine against monkeypox virus and shows it elicits strong antibody responses to key surface antigens in animal models.

bioRxiv · Nov 29, 2022Immunology

Simultaneous and sequential multi-species coronavirus vaccination

L. Peng, Z. Fang, P. A. Renauer, A. McNamara, J. J. Park, Q. Lin, X. Zhou, M. B. Dong, B. Zhu, H. Zhao, C. B. Wilen, S. Chen

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

bioRxiv · May 7, 2022 · PreprintImmunology

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

Z. Fang, L. Peng, Q. Lin, L. Zhou, L. Yang, Y. Feng, P. Ren, P. A. Renauer, J. J. Park, X. Zhou, C. B. Wilen, S. Chen

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

bioRxiv · Mar 22, 2022Immunology

Potent and specific human monoclonal antibodies against SARS-CoV-2 Omicron variant by rapid mRNA immunization of humanized mice

P. Ren, L. Peng, Z. Fang, K. Suzuki, P. A. Renauer, Q. Lin, M. Bai, L. Yang, T. Li, P. Clark, D. Klein, S. Chen

This study develops RAMIHM, a method to generate potent human monoclonal antibodies against SARS-CoV-2 Omicron using mRNA immunization of humanized mice, identifying three highly effective antibodies.

bioRxiv · Mar 17, 2022 · PreprintBioengineering

Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2

Z. Fang, L. Peng, R. Filler, K. Suzuki, A. McNamara, Q. Lin, P. A. Renauer, L. Yang, B. Menasche, A. Sanchez, P. Ren, Q. Xiong, M. Strine, P. Clark, C. Lin, , S. Chen

This study evaluates an Omicron-specific mRNA vaccine, showing it elicits strong antibody responses and outperforms WT boosters against Omicron and Delta variants.

bioRxiv · Feb 14, 2022Immunology