Author

J. J. Park

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Organism:mouse· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

P. A. Renauer· 4 shared S. Chen· 4 shared L. Peng· 3 shared Q. Lin· 3 shared C. B. Wilen· 2 shared L. Yang· 2 shared L. Ye· 2 shared M. Bai· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersImmunology

P. A. Renauer

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

Y.-S. Jang, K. Lee, M. Park, J. J. Park, G. M. Choi, C. Kim, S. B. Dehkohneh, S. Chi, J. Han, M. Y. Song, Y.-H. Han, S.-H. Cha, S. G. Kang

This paper develops APB-R3, a long-acting IL-18 blocker, showing efficacy in reducing inflammation in macrophage activation syndrome and atopic dermatitis models.

bioRxiv · May 30, 2023Immunology

Perturbomics of tumor-infiltrating NK cells

L. Peng, P. A. Renauer, L. Ye, L. Yang, J. J. Park, R. D. Chow, Y. Zhang, Q. Lin, M. Bai, A. Sanchez, Y. Zhang, S. Z. Lam, S. Chen

This study identifies genetic factors limiting NK cell function in tumors using CRISPR screens and single-cell sequencing, highlighting CALHM2 as a target for improving NK cell-based therapies.

bioRxiv · Mar 14, 2023 · PreprintImmunology

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

P. A. Renauer, J. J. Park, M. Bai, A. Acosta, W.-H. Lee, G. H. Lin, Y. Zhang, X. Dai, G. Wang, Y. Errami, T. Wu, P. Clark, L. Ye, Q. Yang, S. Chen

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

bioRxiv · Mar 14, 2023 · PreprintCancer Biology

Simultaneous and sequential multi-species coronavirus vaccination

L. Peng, Z. Fang, P. A. Renauer, A. McNamara, J. J. Park, Q. Lin, X. Zhou, M. B. Dong, B. Zhu, H. Zhao, C. B. Wilen, S. Chen

This study evaluates simultaneous and sequential multi-species coronavirus mRNA vaccination, showing sequential vaccination induces stronger antibody responses against SARS-CoV-2, SARS-CoV, and MERS-CoV.

bioRxiv · May 7, 2022 · PreprintImmunology

Heterotypic vaccination responses against SARS-CoV-2 Omicron BA.2

Z. Fang, L. Peng, Q. Lin, L. Zhou, L. Yang, Y. Feng, P. Ren, P. A. Renauer, J. J. Park, X. Zhou, C. B. Wilen, S. Chen

This study evaluates the effectiveness of WT and variant-specific mRNA vaccines against SARS-CoV-2 Omicron BA.2 subvariant using vaccinated serum from animals.

bioRxiv · Mar 22, 2022Immunology

Second messengers and divergent HD-GYP enzymes regulate 3’,3’-cGAMP signaling

T. A. Wright, L. Jiang, J. J. Park, W. A. Anderson, G. Chen, Z. F. Hallberg, B. Nan, M. C. Hammond

This study identifies cAMP as an activator of GacB and cGAMP-specific phosphodiesterase PmxA, revealing cross-regulation between CDN pathways and predicting non-canonical HD-GYP enzymes.

bioRxiv · Apr 5, 2019Biochemistry

cGAMP signaling controls a transient surface-associated lifestyle

Z. F. Hallberg, C. H. Chan, T. A. Wright, P. J. Kranzusch, K. W. Doxzen, J. J. Park, D. Bond, M. C. Hammond

The paper shows that the GacA enzyme in Geobacter sulfurreducens specifically regulates cGAMP levels to control metal reduction genes, despite in vitro promiscuity, through a kinetic model and structural analysis.

bioRxiv · Dec 12, 2018Biochemistry