Age-dependent loss of cohesion protection in human oocytes
B. P. Mihalas, G. H. Pieper, C. E. Currie, D. A. Kelly, G. M. Hartshorne, A. D. McAinsh, R. A. Anderson, A. L. Marston
This study shows that loss of Sgo2 at the pericentromere bridge in aging human oocytes weakens sister chromatid cohesion, contributing to aneuploidy.
bioRxiv · Jan 13, 2023Cell Biology