Structural and molecular determinants of CCS-mediated copper activation of MEK1/2
M. Grasso, G. J. Bond, Y.-J. Kim, K. B. Alwan, S. Boyd, M. M. Dzebo, S. Valenzuela, T. Tsang, N. A. Schibrowsky, M. L. Matthews, G. M. Burslem, P. Wittung-Stafshede, D. D. Winkler, N. J. Blackburn, R. Marmorstein, D. C. Brady
The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.
bioRxiv · May 1, 2020 · PreprintBiochemistry