Author

M. L. Matthews

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Assay:structural biology· 1

Frequent Co-Authors

A. M. Gregus· 1 shared D. C. Brady· 1 shared D. D. Winkler· 1 shared E. J. Olson· 1 shared E. S. Witze· 1 shared G. J. Bond· 1 shared G. M. Burslem· 1 shared K. A. Bustin· 1 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBiochemistry

A. M. Gregus

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2 papers

Recent·Most cited

Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes

Z. Lin, X. Wang, K. A. Bustin, L. He, R. M. Suciu, N. Schek, M. Ahmadi, K. Hu, E. J. Olson, W. H. Parsons, E. S. Witze, P. D. Morton, A. M. Gregus, M. W. Buczynski, M. L. Matthews

This paper introduces hydrazine-based chemoproteomic probes to target cofactor-dependent enzymes, enabling enzyme discovery and drug development through diverse functional profiling.

bioRxiv · Jun 17, 2020 · PreprintBiochemistry

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

M. Grasso, G. J. Bond, Y.-J. Kim, K. B. Alwan, S. Boyd, M. M. Dzebo, S. Valenzuela, T. Tsang, N. A. Schibrowsky, M. L. Matthews, G. M. Burslem, P. Wittung-Stafshede, D. D. Winkler, N. J. Blackburn, R. Marmorstein, D. C. Brady

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

bioRxiv · May 1, 2020 · PreprintBiochemistry