Author

G. M. Burslem

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 4 Approach:deep learning· 2 Organism:human· 2 Organism:chicken / avian· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

O. Shalem· 2 shared Y. V. Serebrenik· 2 shared C. H. Woodward· 1 shared D. C. Brady· 1 shared D. D. Winkler· 1 shared D. Mani· 1 shared G. F. Papadaki· 1 shared G. J. Bond· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

O. Shalem

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded protein responses

S. E. Sansbury, Y. V. Serebrenik, T. Lapidot, G. M. Burslem, O. Shalem

The paper develops a method to map unfolded protein responses by tagging endogenous proteins and analyzing their localization and stress responses using single-cell RNA sequencing.

bioRxiv · Jul 13, 2023Cell Biology

Pooled endogenous protein tagging and recruitment for scalable discovery of effectors for induced proximity therapeutics

Y. V. Serebrenik, D. Mani, T. Maujean, G. M. Burslem, O. Shalem

This paper introduces a method to systematically discover effector proteins for induced proximity therapeutics by combining high-throughput endogenous protein tagging with small molecule-based recruitment.

bioRxiv · Jul 13, 2023Cell Biology

A Chicken Tapasin ortholog can chaperone empty HLA molecules independently of other peptide-loading components

G. F. Papadaki, C. H. Woodward, M. C. Young, T. J. Winters, G. M. Burslem, N. G. Sgourakis

This study shows that chicken Tapasin can stabilize human HLA molecules without co-chaperones and can bind peptides, suggesting its use in engineering MHC-I ligand exchange.

bioRxiv · Jun 23, 2023 · PreprintImmunology

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

M. Grasso, G. J. Bond, Y.-J. Kim, K. B. Alwan, S. Boyd, M. M. Dzebo, S. Valenzuela, T. Tsang, N. A. Schibrowsky, M. L. Matthews, G. M. Burslem, P. Wittung-Stafshede, D. D. Winkler, N. J. Blackburn, R. Marmorstein, D. C. Brady

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

bioRxiv · May 1, 2020 · PreprintBiochemistry