Author

D. C. Brady

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 4 Research Focus:cancer & tumor microenvironment· 2 Research Focus:development & morphogenesis· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:C. elegans· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

T. Tsang· 3 shared J. M. Posimo· 2 shared A. A. Gudiel· 1 shared B. A. Garcia· 1 shared B. Winterhoff· 1 shared C. Akay-Espinoza· 1 shared C. Arruza· 1 shared C. H. Danan· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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3 shared papersBiochemistry

T. Tsang

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

PERK Kinase Activity is Regulated by Copper Binding-A New Regulatory Paradigm for Modulation of ER Stress Tolerance

S. E. B. Newton, N. R. Beratan, C. Akay-Espinoza, M. K. Bond, X. Shi, J. Perhacs, T. Gidalevitz, D. C. Brady, K. L. Jordan-Sciutto

The paper shows copper binding regulates PERK kinase activity, affecting ER stress tolerance in C. elegans.

bioRxiv · Sep 2, 2022Biochemistry

IGF2BP1/IMP1 deletion enhances a facultative stem cell state via regulation of MAP1LC3B

L. R. Parham, P. A. Williams, P. Chatterji, K. Acheampong, C. H. Danan, K. Katada, X. Ma, L. A. Simon, K. E. Naughton, R. Mizuno, T. Karakasheva, E. A. McMillan, K. A. Whelan, D. C. Brady, S. M. Shaffer, K. E. Hamilton

The paper shows that deleting IGF2BP1/IMP1 enhances autophagy and tissue regeneration by regulating MAP1LC3B through phosphorylation and cell stress.

bioRxiv · Feb 28, 2022 · PreprintCell Biology

PAX8 orchestrates an angiogenic program through interaction with SOX17

D. Chaves-Moreira, M. A. Mitchell, C. Arruza, P. Rawat, S. Sidoli, R. Nameki, J. Reddy, R. I. Corona, S. Ma, B. Winterhoff, G. E. Konecny, B. A. Garcia, D. C. Brady, K. Lawrenson, P. J. Morin, R. Drapkin

This study identifies SOX17 as a PAX8-interacting partner and shows their role in regulating tumor angiogenesis in ovarian cancer, suggesting a new therapeutic target.

bioRxiv · Sep 9, 2020 · PreprintCancer Biology

Structural and molecular determinants of CCS-mediated copper activation of MEK1/2

M. Grasso, G. J. Bond, Y.-J. Kim, K. B. Alwan, S. Boyd, M. M. Dzebo, S. Valenzuela, T. Tsang, N. A. Schibrowsky, M. L. Matthews, G. M. Burslem, P. Wittung-Stafshede, D. D. Winkler, N. J. Blackburn, R. Marmorstein, D. C. Brady

The paper reports the X-ray structure of Cu-MEK1, revealing Cu coordination and CCS-mediated Cu transfer, and identifies molecular mechanisms for Cu-stimulated MEK1 kinase activity.

bioRxiv · May 1, 2020 · PreprintBiochemistry

Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma

T. Tsang, J. M. Posimo, A. A. Gudiel, M. Cicchini, D. M. Feldser, D. C. Brady

This study identifies copper as a regulator of ULK1/2 kinase activity in lung adenocarcinoma, showing that copper chelation can inhibit autophagy and tumor growth.

bioRxiv · Oct 24, 2019Cancer Biology

Activity-Based Ratiometric FRET Probe Reveals Oncogene-Driven Changes in Labile Copper Pools Induced by Altered Glutathione Metabolism

C. Y.-S. Chung, J. M. Posimo, S. Lee, T. Tsang, J. M. Davis, D. C. Brady, C. J. Chang

This paper introduces a ratiometric FRET copper probe, FCP-1, to image labile Cu(I) pools in live cells and shows oncogene-driven changes in glutathione metabolism reduce labile copper availability.

bioRxiv · Jun 24, 2019Biochemistry