Author

G. J. Brouhard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1 Assay:imaging· 1

Frequent Co-Authors

A. G. Hendricks· 3 shared M. Sebastien· 3 shared A. L. Paquette· 2 shared E. N. P. Prowse· 2 shared B. A. Turkalj· 1 shared C.-T. Hsu· 1 shared D. Beaudet· 1 shared H. M. McBride· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

A. G. Hendricks

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment

E. N. P. Prowse, B. A. Turkalj, M. Sebastien, D. Beaudet, H. M. McBride, G. J. Brouhard, M. A. Pouladi, A. G. Hendricks

This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.

bioRxiv · Apr 12, 2024Cell Biology

Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation

M. Sebastien, A. L. Paquette, L. Ferotin, A. G. Hendricks, G. J. Brouhard

The paper develops methods to measure neurite extension and nucleokinesis in iPSC-derived neurons and shows that microtubule-targeting drugs significantly affect these processes.

bioRxiv · Feb 6, 2024Cell Biology

Doublecortin restricts neuronal branching by regulating tubulin polyglutamylation

M. Sebastien, A. L. Paquette, E. N. P. Prowse, A. G. Hendricks, G. J. Brouhard

This study shows DCX regulates neuronal branching by promoting tubulin polyglutamylation, with loss of DCX leading to reduced polyglutamylation and increased neurite branching.

bioRxiv · Jun 2, 2023Cell Biology

Numerical parameter space compression and its application to microtubule dynamic instability

C.-T. Hsu, G. J. Brouhard, P. Francois

The paper introduces a numerical parameter space compression method to identify essential parameters in computational models, applying it to microtubule dynamic instability and showing it reveals low-dimensional structure.

bioRxiv · Nov 21, 2018 · PreprintBiophysics