Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment
E. N. P. Prowse, B. A. Turkalj, M. Sebastien, D. Beaudet, H. M. McBride, G. J. Brouhard, M. A. Pouladi, A. G. Hendricks
This study shows that HTT polyQ expansions disrupt motor and adaptor recruitment to vesicles, causing transport defects and altered responses to neuroinflammatory stress.
bioRxiv · Apr 12, 2024Cell Biology