G. J. Kimmel

Intra-tumor heterogeneity, turnover rate and karyotype space shape susceptibility to missegregation-induced extinction

The paper models chromosome missegregation in tumors to assess extinction risk, finding that intra-tumor heterogeneity and karyotype stability prevent extinction unless turnover rates are extremely high.

Branching and extinction in evolutionary public goods games

This study investigates how cooperation and defection emerge in nonlinear local public goods games through evolutionary branching and population size effects.

Response to CAR T cell therapy can be explained by ecological cell dynamics and stochastic extinction events

The paper develops a mathematical model to explain CAR T cell therapy outcomes by integrating ecological dynamics and stochastic extinction events, showing tumor eradication is a stochastic process.

Modeling adaptive therapy in non-muscle invasive bladder cancer

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

Predictive modeling of co-evolving growing populations

The paper explores density and frequency dependence in tumor growth dynamics using predictive modeling and treatment outcomes.