Author

K. M. Mann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

J. Y. Newberg· 5 shared M. B. Mann· 4 shared A. Aiderus· 2 shared A. L. Meshey· 2 shared A. M. Contreras-Sandoval· 2 shared D. J. Jones· 2 shared J. M. Ward· 2 shared M. A. Black· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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5 shared papersCancer Biology

J. Y. Newberg

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Author profile →

6 papers

Recent·Most cited

RBFOX2 deregulation promotes pancreatic cancer metastasis through alternative splicing

M. Maurin, M. Ranjouri, K. Martin, R. Miner, J. Y. Newberg, D. Du, B. Centeno, J. B. Fleming, X. B. Yu, E. Guccione, M. Black, K. M. Mann

This study identifies RBFOX2 deregulation as a driver of pancreatic cancer metastasis through alternative splicing of ABI1, enhancing cancer cell stemness and invasiveness.

bioRxiv · Jun 1, 2022Cancer Biology

"Transposon Mutagenesis Reveals RBMS3 as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis."

A. Vaishnavi, J. Juan, M. T. Scherzer, J. E. VanVeen, C. Stehn, C. S. Hackett, A. Dupuy, S. A. Chmura, L. van der Weyden, J. Y. Newberg, K. M. Mann, A. Liu, A. G. Rust, W. A. Weiss, D. Adams, , M. McMahon

This paper identifies RBMS3 as a tumor suppressor that cooperates with BRAFV600E to promote malignant lung cancer progression using transposon mutagenesis and CRISPR validation.

bioRxiv · Feb 28, 2022 · PreprintCancer Biology

Insertional mutagenesis defines drivers and evolutionary relationships in pancreatic cancer metastasis

S. Govindaraju, M. Maurin, J. Y. Newberg, D. J. Jones, H. Lee, J. E. Markovitz, M. B. Mann, M. A. Black, K. M. Mann

The paper identifies metastasis-promoting genes and evolutionary relationships in pancreatic cancer using insertional mutagenesis and single-cell sequencing.

bioRxiv · Sep 28, 2020 · PreprintCancer Biology

Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation

A. Aiderus, A. M. Contreras-Sandoval, A. L. Meshey, J. Y. Newberg, J. M. Ward, D. Swing, N. G. Copeland, N. A. Jenkins, K. M. Mann, M. B. Mann

This study uses promoterless transposon mutagenesis to identify tumor suppressor genes driving solid cancers without oncogenic mutations, revealing convergent pathways in cancer progression.

bioRxiv · Aug 17, 2020Cancer Biology

Transposon mutagenesis identifies cooperating genetic drivers during keratinocyte transformation and cutaneous squamous cell carcinoma progression

A. Aiderus, J. Y. Newberg, L. Guzman-Rojas, A. M. Contreras-Sandoval, A. L. Meshey, D. J. Jones, F. Amaya-Manzanares, R. Rangel, J. M. Ward, S. C. Lee, K. H.-K. Ban, K. Rogers, S. M. Rogers, L. Selvanesan, L. A. McNoe, , M. B. Mann

This study uses transposon mutagenesis to identify genetic drivers of keratinocyte transformation and cutaneous squamous cell carcinoma progression in vivo, revealing both known and novel genes involved in the disease.

bioRxiv · Dec 24, 2019Cancer Biology

Modeling adaptive therapy in non-muscle invasive bladder cancer

M. C. Ferrall-Fairbanks, G. J. Kimmel, M. Black, R. Bravo, O. Deac, P. Martinez, M. Myers, F. Nazari, A. Osojnik, H. Subramanian, Y. Viossat, F. Whiting, R. Li, K. M. Mann, P. M. Altrock

This study models adaptive therapy for non-muscle invasive bladder cancer to control tumor size and reduce recurrence by analyzing mutational heterogeneity and cytokine profiles.

bioRxiv · Nov 7, 2019 · PreprintCancer Biology