G. J. Silverman

Dietary tryptophan and genetic susceptibility expand gut microbiota that promote systemic autoimmune activation

The paper shows that dietary tryptophan and genetic factors shape gut microbiota, which in turn influence autoimmune activation in lupus.

Lupus disease flares are concordant with immune responses to blooms of lipoglycan-expressing Ruminococcus blautia gnavus strains arising from unstable gut microbiota communities

Lupus Gut Microbiota Transplants Cause Autoimmunity and Inflammation

This study shows that transferring gut microbiota from SLE patients to germ-free mice induces lupus-like features, suggesting a causal role for gut microbiota in SLE pathogenesis.

Sex-dependent Lupus Ruminococcus blautia gnavus strain induction of zonulin-mediated intestinal permeability and autoimmunity

This study shows that Lupus-associated Ruminococcus blautia gnavus strains increase intestinal permeability and autoimmunity, which can be reversed by larazotide acetate.