PDE1 inhibition modulates Cav1.2 channel to stimulate cardiomyocyte contraction
G. K. Muller, J. Song, V. Jani, Y. Wu, M. E. Anderson, D. A. Kass
This paper investigates how PDE1 inhibition increases cardiac contractility by enhancing Cav1.2 channel conductance through PKA, with less intracellular calcium rise and arrhythmia compared to beta-ARs or PDE3i.
bioRxiv · Nov 5, 2020Pharmacology & Toxicology