V. Jani

The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states.

This study decouples structural OFF/ON states from biochemical SRX/DRX states in myosin using X-ray diffraction and ATP assays in porcine myocardium.

Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure with Pulmonary Hypertension

This study identifies contractile deficits in right ventricular myocytes of HFrEF-PH patients, showing reduced calcium-activated tension and altered myosin ATP turnover, with implications for targeted therapies.

CHARM: COVID-19 Health Action Response for Marines - association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test

CHARM study examines T cell responses in asymptomatic and symptomatic SARS-CoV-2 infected Marines, finding persistent IFN-gamma responses to S, N, and M proteins, with higher frequencies to N in asymptomatic cases.

Myofibril orientation as a metric for characterizing heart disease

This paper introduces a method to quantify myofibrillar orientation in cardiac muscle and shows it detects greater disorientation in diseased tissue compared to healthy controls.

PDE9 Inhibition Activates PPARa to Stimulate Mitochondrial Fat Metabolism and Reduce Cardiometabolic Syndrome

This study shows PDE9 inhibition activates PPARa to enhance mitochondrial fat metabolism and reduce cardiometabolic syndrome in mice, with potential for treating obesity in men and postmenopausal women.

PDE1 inhibition modulates Cav1.2 channel to stimulate cardiomyocyte contraction

This paper investigates how PDE1 inhibition increases cardiac contractility by enhancing Cav1.2 channel conductance through PKA, with less intracellular calcium rise and arrhythmia compared to beta-ARs or PDE3i.