A sound strategy for homology modeling-based affinity maturation of a HIF-1α single-domain intrabody
M. Hu, G. Kang, X. Cheng, J. Wang, R. Li, Z. Bai, D. Yang, H. Huang
This study develops a computational strategy for in silico nanobody affinity maturation, achieving a 17.5-fold improvement in binding affinity for an anti-HIF-1α nanobody.
bioRxiv · May 14, 2020 · PreprintBiochemistry