Bi-steric mTORC1-selective Inhibitors activate 4EBP1 reversing MYC-induced tumorigenesis and synergize with immunotherapy
W. D. Mahauad-Fernandez, Y. C. Yang, I. Lai, J. Park, L. Yao, J. W. Evans, G. L. Burnett, A. Gill, J. A. M. Smith, M. Singh, D. W. Felsher
This study identifies bi-steric mTORC1-selective inhibitors that reactivate 4EBP1, suppress MYC-driven tumors, and enhance immunotherapy in multiple cancer models.
bioRxiv · Feb 4, 2022 · PreprintCancer Biology