Ectopic bone formation and systemic bone loss in a transmembrane TNF-driven model of human spondyloarthritis
E. Christodoulou-Vafeiadou, C. Geka, L. Ntari, K. Kranidioti, E. Argyropoulou, F. Meier, M. Armaka, I. Mourouzis, C. Pantos, M. Rouchota, G. Loudos, M. C. Denis, N. Karagianni, G. Kollias
This paper characterizes a transmembrane TNF-driven mouse model of spondyloarthritis, showing ectopic bone formation, systemic bone loss, and comorbid heart valve pathology, with early anti-TNF treatment reducing inflammation.
bioRxiv · May 14, 2020Pathology