S1P controls endothelial sphingolipid homeostasis via ORMDL
L. Sasset, K. H. Chowdhury, O. L. Manzo, L. Rubinelli, C. Konrad, J. A. Maschek, G. Manfredi, W. L. Holland, A. Di Lorenzo
This study identifies S1P as the sphingolipid sensed by endothelial cells via S1PRs, revealing the S1PR/ORMDLs axis as a regulatory unit controlling sphingolipid homeostasis.
bioRxiv · Oct 22, 2021 · PreprintCell Biology