J. A. Maschek

HAF Prevents Hepatocyte Apoptosis and Hepatocellular Carcinoma through Transcriptional Regulation of the NF-κB pathway.

Inhibition of skeletal muscle Lands cycle ameliorates weakness induced by physical inactivity

This study shows that inhibiting the Lands cycle in skeletal muscle reduces lipid hydroperoxide levels, protecting against disuse-induced atrophy and weakness in mice.

Hepatic IRE1 Protects Against Septic Cardiac Failure

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

Genetic Screen Uncovers a Dual Role for Phospholipids in Mitochondrial-Derived Compartment Biogenesis

The paper identifies distinct roles for cardiolipin and phosphatidylethanolamine in mitochondrial-derived compartment (MDC) biogenesis, showing cardiolipin is required for MDC formation while phosphatidylethanolamine depletion triggers it during amino acid stress.

Weight loss improves skeletal muscle mitochondrial energy efficiency

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

Phosphatidylethanolamine facilitates mitochondrial pyruvate entry to regulate metabolic flexibility

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

Mitochondrial Phosphatidylethanolamine Directly Regulates UCP1 to Promote Brown Adipose Thermogenesis

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

Disruption of CFAP418 interaction with lipids causes abnormal membrane-associated cellular processes in retinal degenerations

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased Diseases

This study identifies a sex-dependent trade-off between hepatic host defense and metabolic programs in mice, showing that BCL6 protects males from infection but increases metabolic disease risk under dietary excess.

Lipid hydroperoxides promote sarcopenia through carbonyl stress

This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.

S1P controls endothelial sphingolipid homeostasis via ORMDL

This study identifies S1P as the sphingolipid sensed by endothelial cells via S1PRs, revealing the S1PR/ORMDLs axis as a regulatory unit controlling sphingolipid homeostasis.

Critical Role for Isoprenoids in Apicoplast Biogenesis by Malaria Parasites

This study identifies a critical role for isoprenoids in apicoplast biogenesis in malaria parasites, showing that IPP and polyprenols are essential for apicoplast membrane fluidity and inheritance.

Serine Palmitoyltransferase Controls Stemness of Intestinal Progenitors

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

Msp1/ATAD1 restores mitochondrial function in Zellweger Spectrum Disease

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

Mitochondrial fatty acid synthesis coordinates mitochondrial oxidative metabolism

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

Schistosoma mansoni infection reprograms the metabolic potential of the myeloid lineage in a mouse model of metabolic syndrome

This study shows that Schistosoma mansoni infection reprograms myeloid cell metabolism in male mice, with sex-dependent effects on cholesterol and glucose metabolism.

The Lands cycle modulates plasma membrane lipid organization and insulin sensitivity in skeletal muscle

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.