Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
M. T. Islam, J. Cai, S. Allen, R. C. Bramwell, J. Mitton, A. G. Horn, W. Zhu, A. J. Donato, W. L. Holland, L. A. Lesniewski, D. G. Moreno, S. I. Bloom
This study shows that reducing Arf6 in endothelial cells impairs insulin-stimulated vasodilation and causes systemic insulin resistance.
bioRxiv · May 2, 2023Physiology
L. Sasset, K. H. Chowdhury, O. L. Manzo, L. Rubinelli, C. Konrad, J. A. Maschek, G. Manfredi, W. L. Holland, A. Di Lorenzo
This study identifies S1P as the sphingolipid sensed by endothelial cells via S1PRs, revealing the S1PR/ORMDLs axis as a regulatory unit controlling sphingolipid homeostasis.
bioRxiv · Oct 22, 2021 · PreprintCell Biology
A.-L. Castell, A. Vivoli, T. S. Tippetts, I. Robillard Frayne, V. S. Moulle, M. Ruiz, J. Ghislain, C. Des Rosiers, W. L. Holland, S. A. Summers, V. Poitout
This study shows that oleate induces β-cell proliferation in rats via unsaturated very long-chain sphingolipids, mediated by ACBP and ELOVL1.
bioRxiv · Jul 16, 2021Cell Biology
S. A. Summers, B. Chaurasia, Y. Li, V. Kaddai, J. L. Wilkerson, J. A. Maschek, J. Cox, P. Wei, C. Bensard, P. J. Meikle, H. Clevers, J. Shayman, Y. Hirabayashi, W. L. Holland, J. Rutter
The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.
bioRxiv · Dec 3, 2020 · PreprintCell Biology
V. Panic, S. Pearson, J. Banks, T. S. Tippetts, S. Lee, J. Simcox, G. Geoghegan, C. Bensard, T. van Ry, W. L. Holland, S. Summers, J. Cox, G. Ducker, J. Rutter, C. Villanueva
This study shows that mitochondrial pyruvate carrier is essential for optimal brown fat thermogenesis, as its deletion impairs cold adaptation and alters metabolic pathways.
bioRxiv · Oct 29, 2019Biochemistry