Author

G. N. Brooke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Azadova· 1 shared A. Marco· 1 shared A. Mohr· 1 shared C. L. Bevan· 1 shared C. T. Clarkson· 1 shared C. Tianyuan· 1 shared E. S. Giotis· 1 shared F. Prischi· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. Azadova

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3 papers

Recent·Most cited

The p90 Ribosomal S6 Kinases 2 and 4 promote Prostate Cancer cell proliferation in androgen-dependent and independent ways

R. Cronin, A. Azadova, A. Marco, P. P. Laissue, G. N. Brooke, F. Prischi

This study shows RSK2 and RSK4 promote prostate cancer proliferation through distinct mechanisms, both dependent and independent of androgen signaling.

bioRxiv · Mar 4, 2024 · PreprintCancer Biology

The antiviral potential of the antiandrogen enzalutamide and the viral-androgen interplay in seasonal coronaviruses

O. D. Ogunjinmi, T. Abdullahi, R.-A. Somji, C. L. Bevan, W. S. Barclay, N. J. Temperton, G. N. Brooke, E. S. Giotis

This study investigates enzalutamide's antiviral effects against seasonal coronaviruses and identifies differences in viral-androgen signaling interactions between HCoV-229E and HCoV-OC43.

bioRxiv · Nov 25, 2023 · PreprintMicrobiology

Fas-threshold signalling in MSCs causes tumour progression and metastasis

A. Mohr, R. Zwacka, G. N. Brooke, V. B. Teif, C. T. Clarkson, C. Tianyuan

This study shows Fas-threshold signalling in MSCs promotes tumour progression and metastasis by increasing MSC numbers and cytokine production in pancreatic cancer.

bioRxiv · Dec 2, 2020Cancer Biology